Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border
© 2016 Elsevier B.V. Malaria transmission along international borders of the Greater Mekong Subregion is a big challenge for regional malaria elimination. At the Thai-Myanmar border, Plasmodium falciparum cases have dropped dramatically; however, increasing P. vivax prevalence and the emerging repor...
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th-mahidol.428992019-03-14T15:03:56Z Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border Bhavna Gupta Daniel M. Parker Qi Fan B. P.Niranjan Reddy Guiyun Yan Jetsumon Sattabongkot Liwang Cui Pennsylvania State University Mahidol University Dalian Institute of Biotechnology University of California, Irvine Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine © 2016 Elsevier B.V. Malaria transmission along international borders of the Greater Mekong Subregion is a big challenge for regional malaria elimination. At the Thai-Myanmar border, Plasmodium falciparum cases have dropped dramatically; however, increasing P. vivax prevalence and the emerging reports on hidden malaria burden due to asymptomatic infections demand attention. We conducted cross-sectional surveys to detect asymptomatic malaria infections in a small village located at Thai-Myanmar border and genotyped P. vivax infections in order to understand the level of genetic diversity on such a microgeographic scale. PCR/RFLP and DNA sequencing identified high levels of genetic polymorphisms at both Pvmsp3α and Pvmsp3β loci among P. vivax infections. Combining the PCR/RFLP patterns of Pvmsp3α and Pvmsp3β, a total of 10 genotypes were observed among 17 samples, while concatenated DNA sequences of Pvmsp3α and 3β generated 14 haplotypes with haplotype diversity of 0.97. These markedly diverse parasites on a microgeographic scale suggest the circulation of a considerably large parasite population at the international border. 2018-12-11T01:55:54Z 2019-03-14T08:03:56Z 2018-12-11T01:55:54Z 2019-03-14T08:03:56Z 2016-11-01 Article Infection, Genetics and Evolution. Vol.45, (2016), 341-346 10.1016/j.meegid.2016.09.021 15677257 15671348 2-s2.0-84988985916 https://repository.li.mahidol.ac.th/handle/123456789/42899 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988985916&origin=inward |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine Bhavna Gupta Daniel M. Parker Qi Fan B. P.Niranjan Reddy Guiyun Yan Jetsumon Sattabongkot Liwang Cui Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border |
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© 2016 Elsevier B.V. Malaria transmission along international borders of the Greater Mekong Subregion is a big challenge for regional malaria elimination. At the Thai-Myanmar border, Plasmodium falciparum cases have dropped dramatically; however, increasing P. vivax prevalence and the emerging reports on hidden malaria burden due to asymptomatic infections demand attention. We conducted cross-sectional surveys to detect asymptomatic malaria infections in a small village located at Thai-Myanmar border and genotyped P. vivax infections in order to understand the level of genetic diversity on such a microgeographic scale. PCR/RFLP and DNA sequencing identified high levels of genetic polymorphisms at both Pvmsp3α and Pvmsp3β loci among P. vivax infections. Combining the PCR/RFLP patterns of Pvmsp3α and Pvmsp3β, a total of 10 genotypes were observed among 17 samples, while concatenated DNA sequences of Pvmsp3α and 3β generated 14 haplotypes with haplotype diversity of 0.97. These markedly diverse parasites on a microgeographic scale suggest the circulation of a considerably large parasite population at the international border. |
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Pennsylvania State University |
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Pennsylvania State University Bhavna Gupta Daniel M. Parker Qi Fan B. P.Niranjan Reddy Guiyun Yan Jetsumon Sattabongkot Liwang Cui |
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Article |
author |
Bhavna Gupta Daniel M. Parker Qi Fan B. P.Niranjan Reddy Guiyun Yan Jetsumon Sattabongkot Liwang Cui |
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Bhavna Gupta |
title |
Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border |
title_short |
Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border |
title_full |
Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border |
title_fullStr |
Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border |
title_full_unstemmed |
Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border |
title_sort |
microgeographically diverse plasmodium vivax populations at the thai-myanmar border |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/42899 |
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1763489524627800064 |