Proof-of concept that an acute trophic factors intervention after spinal cord injury provides an adequate niche for neuroprotection, recruitment of nestin-expressing progenitors and regeneration

• Main Authors: Warin Krityakiarana, Paul M. Zhao, Kevin Nguyen, Fernando Gomez-Pinilla, Naiphinich Kotchabhakdi, Jean De Vellis, Araceli Espinosa-Jeffrey
• Other Authors: Jane & Terry Semel Institute for Neuroscience & Human Behavior
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/43101
• Institution: Mahidol University

© Springer Science+Business Media New York 2016. Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic s...