A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

• Main Authors: Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H.I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H.Y. Jiang, Dennis E. Kyle, John H. Adams
• Other Authors: Institut Pasteur du Cambodge
• Format: Article
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Physics and Astronomy
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/44988
• Institution: Mahidol University

© 2018 The Author(s). Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falciparum lack the efficiency necessary for rapid identification and...