Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses

by Carola Schäfer, Nicholas Dambrauskas, Laura M. Reynolds, Olesya Trakhimets, Andrew Raappana, Erika L. Flannery, Wanlapa Roobsoong, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, Stefan H.I. Kappe, D. Noah Sather
Published 2022

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

by Xue Li, Sudhir Kumar, Marina McDew-White, Meseret Haile, Ian H. Cheeseman, Scott Emrich, Katie Button-Simons, François Nosten, Stefan H.I. Kappe, Michael T. Ferdig, Tim J.C. Anderson, Ashley M. Vaughan
Published 2020

Plasmodium falciparum genetic crosses in a humanized mouse model

by Ashley M. Vaughan, Richard S. Pinapati, Ian H. Cheeseman, Nelly Camargo, Matthew Fishbaugher, Lisa A. Checkley, Shalini Nair, Carolyn A. Hutyra, François H. Nosten, Timothy J.C. Anderson, Michael T. Ferdig, Stefan H.I. Kappe
Published 2018

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites

by Nil Gural, Liliana Mancio-Silva, Alex B. Miller, Ani Galstian, Vincent L. Butty, Stuart S. Levine, Rapatbhorn Patrapuvich, Salil P. Desai, Sebastian A. Mikolajczak, Stefan H.I. Kappe, Heather E. Fleming, Sandra March, Jetsumon Sattabongkot, Sangeeta N. Bhatia
Published 2019

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages 11 Medical and Health Sciences 1108 Medical Microbiology

by Carola Schafer, Nicholas Dambrauskas, Ryan W. Steel, Sara Carbonetti, Vorada Chuenchob, Erika L. Flannery, Vladimir Vigdorovich, Brian G. Oliver, Wanlapa Roobsoong, Steven P. Maher, Dennis Kyle, Jetsumon Sattabongkot, Stefan H.I. Kappe, Sebastian A. Mikolajczak, D. Noah Sather
Published 2019

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

by Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe
Published 2018

Characterization of Plasmodium vivax Proteins in plasma-derived exosomes from Malaria-infected liver-chimeric humanized mice

by Melisa Gualdrón-López, Erika L. Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Dietmar Fernandez-Orth, Joan Segui-Barber, Felix Royo, Juan M. Falcón-Pérez, Carmen Fernandez-Becerra, Marcus V.G. Lacerda, Stefan H.I. Kappe, Jetsumon Sattabongkot, Juan R. Gonzalez, Sebastian A. Mikolajczak, Hernando A. del Portillo
Published 2019

The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes

by Silvia A. Arredondo, Kristian E. Swearingen, Thomas Martinson, Ryan Steel, Dorender A. Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G. Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Mikolajczak, Ashley M. Vaughan, Motomi Torii, Robert L. Moritz, Stefan H.I. Kappe
Published 2019

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

by Carola Schäfer, Wanlapa Roobsoong, Niwat Kangwanrangsan, Martino Bardelli, Thomas A. Rawlinson, Nicholas Dambrauskas, Olesya Trakhimets, Chaitra Parthiban, Debashree Goswami, Laura M. Reynolds, Spencer Y. Kennedy, Erika L. Flannery, Sean C. Murphy, D. Noah Sather, Simon J. Draper, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, Stefan H.I. Kappe
Published 2020

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing mal...

by Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob
Published 2020

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

by Katelyn Vendrely Brenneman, Xue Li, Sudhir Kumar, Elizabeth Delgado, Lisa A. Checkley, Douglas A. Shoue, Ann Reyes, Biley A. Abatiyow, Meseret T. Haile, Rupam Tripura, Tom Peto, Dysoley Lek, Katrina A. Button-Simons, Stefan H.I. Kappe, Mehul Dhorda, François Nosten, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Michael T. Ferdig, Tim J.C. Anderson
Published 2022

A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media

by Sudhir Kumar, Xue Li, Marina McDew-White, Ann Reyes, Elizabeth Delgado, Abeer Sayeed, Meseret T. Haile, Biley A. Abatiyow, Spencer Y. Kennedy, Nelly Camargo, Lisa A. Checkley, Katelyn V. Brenneman, Katrina A. Button-Simons, Manoj T. Duraisingh, Ian H. Cheeseman, Stefan H.I. Kappe, François Nosten, Michael T. Ferdig, Ashley M. Vaughan, Tim J.C. Anderson
Published 2022

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

by Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H.I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H.Y. Jiang, Dennis E. Kyle, John H. Adams
Published 2019

Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum (Nature Communications (2018) DOI: 10.1038/s41...

by Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H.I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H.Y. Jiang, Dennis E. Kyle, John H. Adams
Published 2019