Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases

© 2018 The Authors Extracellular growth factors signal to transcription factors via a limited number of cytoplasmic kinase cascades. It remains unclear how such cascades encode ligand identities and concentrations. In this paper, we use live-cell imaging and statistical modeling to study FOXO3, a tr...

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Bibliographic Details
Main Authors: Somponnat Sampattavanich, Bernhard Steiert, Bernhard A. Kramer, Benjamin M. Gyori, John G. Albeck, Peter K. Sorger
Other Authors: Universität Freiburg im Breisgau
Format: Article
Published: 2019
Subjects:
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/45130
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Institution: Mahidol University