Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

© 2018 The Author(s). Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylacti...

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Bibliographic Details
Main Authors: Peter Abbink, Rafael A. Larocca, Wanwisa Dejnirattisai, Rebecca Peterson, Joseph P. Nkolola, Erica N. Borducchi, Piyada Supasa, Juthathip Mongkolsapaya, Gavin R. Screaton, Dan H. Barouch
Other Authors: University of Oxford
Format: Article
Published: 2019
Subjects:
Biochemistry, Genetics and Molecular Biology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/45157
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Institution: Mahidol University
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Summary:© 2018 The Author(s). Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.

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