Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing

• Main Authors: Joseph Hawksworth, Timothy J. Satchwell, Marjolein Meinders, Deborah E. Daniels, Fiona Regan, Nicole M. Thornton, Marieangela C. Wilson, Johannes G.G. Dobbe, Geert J. Streekstra, Kongtana Trakarnsanga, Kate J. Heesom, David J. Anstee, Jan Frayne, Ashley M. Toye
• Other Authors: Imperial College Healthcare NHS Trust
• Format: Article
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/45158
• Institution: Mahidol University

© 2018 The Authors. Published under the terms of the CC BY 4.0 license Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility a...