Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials

© 2017 Aims To compare outcomes between Asian and non-Asian patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetic drugs (OADs) initiating insulin glargine 100 units (U)/mL (Gla-100) in randomised controlled clinical trials. Methods Post hoc analysis of patient-level data (...

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Main Authors: Juliana C.N. Chan, Pongamorn Bunnag, Siew P. Chan, Iris T.I. Tan, Shih Tzer Tsai, Ling Gao, Wolfgang Landgraf
Other Authors: Cheng Hsin General Hospital
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Published: 2019
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/45341
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spelling th-mahidol.453412019-08-28T13:40:13Z Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials Juliana C.N. Chan Pongamorn Bunnag Siew P. Chan Iris T.I. Tan Shih Tzer Tsai Ling Gao Wolfgang Landgraf Cheng Hsin General Hospital University of the Philippines Manila Prince of Wales Hospital Hong Kong Faculty of Medicine, Ramathibodi Hospital, Mahidol University University of Malaya Medical Centre Analysta Inc. Sanofi Biochemistry, Genetics and Molecular Biology Medicine © 2017 Aims To compare outcomes between Asian and non-Asian patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetic drugs (OADs) initiating insulin glargine 100 units (U)/mL (Gla-100) in randomised controlled clinical trials. Methods Post hoc analysis of patient-level data (Asian n = 235; non-Asian n = 3351) from 16 trials. Results At baseline, Asian patients were younger with lower body mass index (BMI), fasting C-peptide, and fasting plasma glucose (FPG) than non-Asian patients (all P <.001). Asian patients had a higher mean glycosylated haemoglobin (HbA1c) at Week 24 and less reduction in HbA1c from baseline (7.4% vs. 7.2%; −1.3% vs. −1.6%, respectively; P =.0001), and were less likely to achieve HbA1c <7.0% (40% vs. 47%; P =.002) than non-Asian patients. Reductions in FPG and rates of hypoglycaemia were similar between Asian and non-Asian patients. Asian patients had less weight gain than non-Asian patients (+1.3 vs. +1.9 kg, respectively, P =.013). Conclusions In our post hoc meta-analysis, Gla-100 effectively lowers HbA1c and FPG in Asian patients with T2D uncontrolled on OADs with similar incidence of hypoglycaemia and less absolute weight gain compared with non-Asian patients. At a similar FPG reduction, fewer Asian patients achieved HbA1c target <7.0%, suggesting that prandial glucose needs to be addressed. 2019-08-23T10:42:00Z 2019-08-23T10:42:00Z 2018-01-01 Article Diabetes Research and Clinical Practice. Vol.135, (2018), 199-205 10.1016/j.diabres.2017.11.025 18728227 01688227 2-s2.0-85037357363 https://repository.li.mahidol.ac.th/handle/123456789/45341 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85037357363&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Juliana C.N. Chan
Pongamorn Bunnag
Siew P. Chan
Iris T.I. Tan
Shih Tzer Tsai
Ling Gao
Wolfgang Landgraf
Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
description © 2017 Aims To compare outcomes between Asian and non-Asian patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetic drugs (OADs) initiating insulin glargine 100 units (U)/mL (Gla-100) in randomised controlled clinical trials. Methods Post hoc analysis of patient-level data (Asian n = 235; non-Asian n = 3351) from 16 trials. Results At baseline, Asian patients were younger with lower body mass index (BMI), fasting C-peptide, and fasting plasma glucose (FPG) than non-Asian patients (all P <.001). Asian patients had a higher mean glycosylated haemoglobin (HbA1c) at Week 24 and less reduction in HbA1c from baseline (7.4% vs. 7.2%; −1.3% vs. −1.6%, respectively; P =.0001), and were less likely to achieve HbA1c <7.0% (40% vs. 47%; P =.002) than non-Asian patients. Reductions in FPG and rates of hypoglycaemia were similar between Asian and non-Asian patients. Asian patients had less weight gain than non-Asian patients (+1.3 vs. +1.9 kg, respectively, P =.013). Conclusions In our post hoc meta-analysis, Gla-100 effectively lowers HbA1c and FPG in Asian patients with T2D uncontrolled on OADs with similar incidence of hypoglycaemia and less absolute weight gain compared with non-Asian patients. At a similar FPG reduction, fewer Asian patients achieved HbA1c target <7.0%, suggesting that prandial glucose needs to be addressed.
author2 Cheng Hsin General Hospital
author_facet Cheng Hsin General Hospital
Juliana C.N. Chan
Pongamorn Bunnag
Siew P. Chan
Iris T.I. Tan
Shih Tzer Tsai
Ling Gao
Wolfgang Landgraf
format Article
author Juliana C.N. Chan
Pongamorn Bunnag
Siew P. Chan
Iris T.I. Tan
Shih Tzer Tsai
Ling Gao
Wolfgang Landgraf
author_sort Juliana C.N. Chan
title Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
title_short Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
title_full Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
title_fullStr Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
title_full_unstemmed Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials
title_sort glycaemic responses in asian and non-asian people with type 2 diabetes initiating insulin glargine 100 units/ml: a patient-level pooled analysis of 16 randomised controlled trials
publishDate 2019
url https://repository.li.mahidol.ac.th/handle/123456789/45341
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