The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes

• Main Authors: Silvia A. Arredondo, Kristian E. Swearingen, Thomas Martinson, Ryan Steel, Dorender A. Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G. Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Mikolajczak, Ashley M. Vaughan, Motomi Torii, Robert L. Moritz, Stefan H.I. Kappe
• Other Authors: Children's Hospital and Regional Medical Center
• Format: Article
• Published: 2019
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/46065
• Institution: Mahidol University

Within the liver, Plasmodium sporozoites traverse cells searching for a "suitable" hepatocyte, invading these cells through a process that results in the formation of a parasitophorous vacuole (PV), within which the parasite undergoes intracellular replication as a liver stage. It was prev...