Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity

Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity

© 2018 by the authors. One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-L-tryptophan. Their structu...

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Main Authors: Cong Wang, Adeep Monger, Liping Wang, Peng Fu, Pawinee Piyachaturawat, Arthit Chairoungdua, Weiming Zhu
Other Authors: Guangxi University for Nationalities
Format: Article
Published: 2019
Subjects:
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/47312
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spelling th-mahidol.473122019-08-28T13:51:39Z Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity Cong Wang Adeep Monger Liping Wang Peng Fu Pawinee Piyachaturawat Arthit Chairoungdua Weiming Zhu Guangxi University for Nationalities Ocean University of China Chinese Academy of Sciences Mahidol University Qingdao National Laboratory for Marine Science and Technology Pharmacology, Toxicology and Pharmaceutics © 2018 by the authors. One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-L-tryptophan. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 potently induced apoptosis of gastric cancer cells by inhibiting topoisomerase IIα enzyme activity and reducing the expression of antiapoptosis protein level. Compound 3 displayed moderate cytotoxicity against the A549 and MCF-7 cell lines with IC50 values of 1.2 ± 0.05 µM, 1.6 ± 0.09 µM, respectively. 2019-08-28T06:51:39Z 2019-08-28T06:51:39Z 2018-05-01 Article Marine Drugs. Vol.16, No.5 (2018) 10.3390/md16050168 16603397 2-s2.0-85047176616 https://repository.li.mahidol.ac.th/handle/123456789/47312 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047176616&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Cong Wang
Adeep Monger
Liping Wang
Peng Fu
Pawinee Piyachaturawat
Arthit Chairoungdua
Weiming Zhu
Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
description © 2018 by the authors. One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-L-tryptophan. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 potently induced apoptosis of gastric cancer cells by inhibiting topoisomerase IIα enzyme activity and reducing the expression of antiapoptosis protein level. Compound 3 displayed moderate cytotoxicity against the A549 and MCF-7 cell lines with IC50 values of 1.2 ± 0.05 µM, 1.6 ± 0.09 µM, respectively.
author2 Guangxi University for Nationalities
author_facet Guangxi University for Nationalities
Cong Wang
Adeep Monger
Liping Wang
Peng Fu
Pawinee Piyachaturawat
Arthit Chairoungdua
Weiming Zhu
format Article
author Cong Wang
Adeep Monger
Liping Wang
Peng Fu
Pawinee Piyachaturawat
Arthit Chairoungdua
Weiming Zhu
author_sort Cong Wang
title Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
title_short Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
title_full Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
title_fullStr Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
title_full_unstemmed Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
title_sort precursor-directed generation of indolocarbazoles with topoisomerase iiα inhibitory activity
publishDate 2019
url https://repository.li.mahidol.ac.th/handle/123456789/47312
_version_ 1763490247682818048

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