Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

• Main Authors: Jakub Gruszczyk, Usheer Kanjee, Li Jin Chan, Sébastien Menant, Benoit Malleret, Nicholas T.Y. Lim, Christoph Q. Schmidt, Yee Foong Mok, Kai Min Lin, Richard D. Pearson, Gabriel Rangel, Brian J. Smith, Melissa J. Call, Michael P. Weekes, Michael D.W. Griffin, James M. Murphy, Jonathan Abraham, Kanlaya Sriprawat, Maria J. Menezes, Marcelo U. Ferreira, Bruce Russell, Laurent Renia, Manoj T. Duraisingh, Wai Hong Tham
• Other Authors: A-Star, Singapore Immunology Network
• Format: Article
• Published: 2019
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/47538
• Institution: Mahidol University

Plasmodium vivax shows a strict host tropism for reticulocytes.We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b).We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecu...