Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Plasmodium vivax shows a strict host tropism for reticulocytes.We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b).We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecu...
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th-mahidol.475382019-08-28T14:13:59Z Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax Jakub Gruszczyk Usheer Kanjee Li Jin Chan Sébastien Menant Benoit Malleret Nicholas T.Y. Lim Christoph Q. Schmidt Yee Foong Mok Kai Min Lin Richard D. Pearson Gabriel Rangel Brian J. Smith Melissa J. Call Michael P. Weekes Michael D.W. Griffin James M. Murphy Jonathan Abraham Kanlaya Sriprawat Maria J. Menezes Marcelo U. Ferreira Bruce Russell Laurent Renia Manoj T. Duraisingh Wai Hong Tham A-Star, Singapore Immunology Network Cambridge Institute for Medical Research Harvard School of Public Health Walter and Eliza Hall Institute of Medical Research Yong Loo Lin School of Medicine University of Melbourne University of Otago Mahidol University Universität Ulm Universidade de Sao Paulo - USP La Trobe University Wellcome Sanger Institute Harvard Medical School Li Ka Shing Centre for Health Information and Discovery Multidisciplinary Plasmodium vivax shows a strict host tropism for reticulocytes.We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b).We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecular basis for TfR1 recognition.We validated TfR1 as the biological target of PvRBP2b engagement by means of TfR1 expression knockdown analysis. TfR1 mutant cells deficient in PvRBP2b binding were refractory to invasion of P. vivax but not to invasion of P. falciparum. Using Brazilian and Thai clinical isolates, we show that PvRBP2b monoclonal antibodies that inhibit reticulocyte binding also block P. vivax entry into reticulocytes.These data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion. 2019-08-28T07:13:59Z 2019-08-28T07:13:59Z 2018-01-05 Article Science. Vol.359, No.6371 (2018), 48-55 10.1126/science.aan1078 10959203 00368075 2-s2.0-85040101798 https://repository.li.mahidol.ac.th/handle/123456789/47538 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040101798&origin=inward |
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Multidisciplinary Jakub Gruszczyk Usheer Kanjee Li Jin Chan Sébastien Menant Benoit Malleret Nicholas T.Y. Lim Christoph Q. Schmidt Yee Foong Mok Kai Min Lin Richard D. Pearson Gabriel Rangel Brian J. Smith Melissa J. Call Michael P. Weekes Michael D.W. Griffin James M. Murphy Jonathan Abraham Kanlaya Sriprawat Maria J. Menezes Marcelo U. Ferreira Bruce Russell Laurent Renia Manoj T. Duraisingh Wai Hong Tham Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax |
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Plasmodium vivax shows a strict host tropism for reticulocytes.We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b).We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecular basis for TfR1 recognition.We validated TfR1 as the biological target of PvRBP2b engagement by means of TfR1 expression knockdown analysis. TfR1 mutant cells deficient in PvRBP2b binding were refractory to invasion of P. vivax but not to invasion of P. falciparum. Using Brazilian and Thai clinical isolates, we show that PvRBP2b monoclonal antibodies that inhibit reticulocyte binding also block P. vivax entry into reticulocytes.These data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion. |
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A-Star, Singapore Immunology Network |
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A-Star, Singapore Immunology Network Jakub Gruszczyk Usheer Kanjee Li Jin Chan Sébastien Menant Benoit Malleret Nicholas T.Y. Lim Christoph Q. Schmidt Yee Foong Mok Kai Min Lin Richard D. Pearson Gabriel Rangel Brian J. Smith Melissa J. Call Michael P. Weekes Michael D.W. Griffin James M. Murphy Jonathan Abraham Kanlaya Sriprawat Maria J. Menezes Marcelo U. Ferreira Bruce Russell Laurent Renia Manoj T. Duraisingh Wai Hong Tham |
format |
Article |
author |
Jakub Gruszczyk Usheer Kanjee Li Jin Chan Sébastien Menant Benoit Malleret Nicholas T.Y. Lim Christoph Q. Schmidt Yee Foong Mok Kai Min Lin Richard D. Pearson Gabriel Rangel Brian J. Smith Melissa J. Call Michael P. Weekes Michael D.W. Griffin James M. Murphy Jonathan Abraham Kanlaya Sriprawat Maria J. Menezes Marcelo U. Ferreira Bruce Russell Laurent Renia Manoj T. Duraisingh Wai Hong Tham |
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Jakub Gruszczyk |
title |
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax |
title_short |
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax |
title_full |
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax |
title_fullStr |
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax |
title_full_unstemmed |
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax |
title_sort |
transferrin receptor 1 is a reticulocyte-specific receptor for plasmodium vivax |
publishDate |
2019 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/47538 |
_version_ |
1763496778209951744 |