HRP2: Transforming Malaria Diagnosis, but with Caveats
© 2019 The Authors The major growth in point-of-care malaria diagnosis over the past decade has been based on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect Plasmodium falciparum via its abundant histidine-rich protein 2 (HRP2). Here, we review the discovery and...
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th-mahidol.496162020-01-27T10:34:52Z HRP2: Transforming Malaria Diagnosis, but with Caveats Kristin E. Poti David J. Sullivan Arjen M. Dondorp Charles J. Woodrow University of Oxford Mahidol University Nuffield Department of Clinical Medicine Johns Hopkins Bloomberg School of Public Health Immunology and Microbiology Medicine © 2019 The Authors The major growth in point-of-care malaria diagnosis over the past decade has been based on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect Plasmodium falciparum via its abundant histidine-rich protein 2 (HRP2). Here, we review the discovery and biology of HRP2, as well as the strengths and weaknesses of HRP2-based diagnosis compared with alternative antigens. We highlight recent studies describing HRP2 deletion in Latin America, Eritrea, and possibly other regions, and the methodological challenges of confirming deletion of the pfhrp2 gene. We also discuss the mechanism of persistent HRP2 positivity after effective antimalarial treatment, along with other emerging HRP2-based applications, including detection of submicroscopic malaria and diagnosis of severe malaria. 2020-01-27T03:33:43Z 2020-01-27T03:33:43Z 2020-02-01 Review Trends in Parasitology. Vol.36, No.2 (2020), 112-126 10.1016/j.pt.2019.12.004 14715007 14714922 2-s2.0-85076512587 https://repository.li.mahidol.ac.th/handle/123456789/49616 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076512587&origin=inward |
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Immunology and Microbiology Medicine Kristin E. Poti David J. Sullivan Arjen M. Dondorp Charles J. Woodrow HRP2: Transforming Malaria Diagnosis, but with Caveats |
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© 2019 The Authors The major growth in point-of-care malaria diagnosis over the past decade has been based on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect Plasmodium falciparum via its abundant histidine-rich protein 2 (HRP2). Here, we review the discovery and biology of HRP2, as well as the strengths and weaknesses of HRP2-based diagnosis compared with alternative antigens. We highlight recent studies describing HRP2 deletion in Latin America, Eritrea, and possibly other regions, and the methodological challenges of confirming deletion of the pfhrp2 gene. We also discuss the mechanism of persistent HRP2 positivity after effective antimalarial treatment, along with other emerging HRP2-based applications, including detection of submicroscopic malaria and diagnosis of severe malaria. |
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University of Oxford |
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University of Oxford Kristin E. Poti David J. Sullivan Arjen M. Dondorp Charles J. Woodrow |
format |
Review |
author |
Kristin E. Poti David J. Sullivan Arjen M. Dondorp Charles J. Woodrow |
author_sort |
Kristin E. Poti |
title |
HRP2: Transforming Malaria Diagnosis, but with Caveats |
title_short |
HRP2: Transforming Malaria Diagnosis, but with Caveats |
title_full |
HRP2: Transforming Malaria Diagnosis, but with Caveats |
title_fullStr |
HRP2: Transforming Malaria Diagnosis, but with Caveats |
title_full_unstemmed |
HRP2: Transforming Malaria Diagnosis, but with Caveats |
title_sort |
hrp2: transforming malaria diagnosis, but with caveats |
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2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/49616 |
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1763496717439729664 |