Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization

• Main Authors: Ninticha Thavoncharoensub, Kento Maruyama, Choon Han Heh, Kok Hoong Leong, Hui Shi, Yoshiharu Shigematsu, Shigeki Sasaki, Yosuke Taniguchi
• Other Authors: University of Malaya
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/50108
• Institution: Mahidol University

© 2019, © 2019 Taylor & Francis Group, LLC. 8-OxodGTP is generated by the reaction between dGTP and reactive oxygen species and a considered mutagenic nucleotide. It can be incorporated into the duplex DNA during replication processes by the DNA polymerase, and thus the repair enzyme removes o...