Characterization of FOXO acetylation
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes. Its inactivation is closely associated w...
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th-mahidol.503822020-01-27T14:57:24Z Characterization of FOXO acetylation Shang Yao Zimam Mahmud Nikoleta Sachini Sathid Aimjongjun Paula Saavedra-García Eric W.F. Lam Imperial College London Mahidol University Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas Panepistimio Kritis Biochemistry, Genetics and Molecular Biology © 2019, Springer Science+Business Media, LLC, part of Springer Nature. FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes. Its inactivation is closely associated with tumorigenesis and cancer progression. On the other hand, sirtuin proteins have been demonstrated to be able to deacetylate, thus causing FOXO3 inactivation at the posttranslational level. Therefore, targeting sirtuin proteins renders new avenues for breast cancer treatment. Here, we describe three procedures for studying FOXO3 posttranslational modifications controlled by sirtuin proteins in cancer cells. 2020-01-27T07:57:24Z 2020-01-27T07:57:24Z 2019-01-01 Chapter Methods in Molecular Biology. Vol.1890, (2019), 77-90 10.1007/978-1-4939-8900-3_7 10643745 2-s2.0-85056409569 https://repository.li.mahidol.ac.th/handle/123456789/50382 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056409569&origin=inward |
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Biochemistry, Genetics and Molecular Biology Shang Yao Zimam Mahmud Nikoleta Sachini Sathid Aimjongjun Paula Saavedra-García Eric W.F. Lam Characterization of FOXO acetylation |
| description |
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes. Its inactivation is closely associated with tumorigenesis and cancer progression. On the other hand, sirtuin proteins have been demonstrated to be able to deacetylate, thus causing FOXO3 inactivation at the posttranslational level. Therefore, targeting sirtuin proteins renders new avenues for breast cancer treatment. Here, we describe three procedures for studying FOXO3 posttranslational modifications controlled by sirtuin proteins in cancer cells. |
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Imperial College London |
| author_facet |
Imperial College London Shang Yao Zimam Mahmud Nikoleta Sachini Sathid Aimjongjun Paula Saavedra-García Eric W.F. Lam |
| format |
Chapter |
| author |
Shang Yao Zimam Mahmud Nikoleta Sachini Sathid Aimjongjun Paula Saavedra-García Eric W.F. Lam |
| author_sort |
Shang Yao |
| title |
Characterization of FOXO acetylation |
| title_short |
Characterization of FOXO acetylation |
| title_full |
Characterization of FOXO acetylation |
| title_fullStr |
Characterization of FOXO acetylation |
| title_full_unstemmed |
Characterization of FOXO acetylation |
| title_sort |
characterization of foxo acetylation |
| publishDate |
2020 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/50382 |
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1763495601987649536 |