Characterization of the ATP4 ion pump in Toxoplasma gondii

• Main Authors: Adele M. Lehane, Adelaide S.M. Dennis, Katherine O. Bray, Dongdi Li, Esther Rajendran, James M. McCoy, Hillary M. McArthur, Markus Winterberg, Farid Rahimi, Christopher J. Tonkin, Kiaran Kirk, Giel G. Van Dooren
• Other Authors: Walter and Eliza Hall Institute of Medical Research
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/50388
• Institution: Mahidol University

© 2019 Lehane et al. The Plasmodium falciparum ATPase PfATP4 isthetarget of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4 was originally annotated as a Ca2 transporter, but recent evidence suggests that it is a Na efflux pump, extruding Na in exc...