Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram
© 2019 American Association for Pediatric Ophthalmology and Strabismus Purpose: To assess the RETeval (LKC Technologies, Gaithersburg, MD) handheld electroretingram (ERG) device as a screening tool for cone dysfunction in pediatric patients by comparing it to conventional ERG. Methods: Patients sche...
Saved in:
Main Authors: | , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2020
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/51918 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.51918 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.519182020-01-27T17:09:24Z Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram Carla J. Osigian Sara F. Grace Kara M. Cavuoto William J. Feuer Mehdi Tavakoli Piangporn Saksiriwutto Mu Liu Hilda Capo Byron L. Lam The University of North Carolina at Chapel Hill Bascom Palmer Eye Institute Faculty of Medicine, Siriraj Hospital, Mahidol University Medicine © 2019 American Association for Pediatric Ophthalmology and Strabismus Purpose: To assess the RETeval (LKC Technologies, Gaithersburg, MD) handheld electroretingram (ERG) device as a screening tool for cone dysfunction in pediatric patients by comparing it to conventional ERG. Methods: Patients scheduled for ERG under general anesthesia (GA) underwent three tests: (1) RETeval standard 30 Hz cone flicker ERG using skin electrodes prior to GA, (2) E3 Diagnosys (Diagnosys LLC, Lowell, MA) conventional complete standard protocol full-field ERG using bipolar contact lens electrodes and handheld stimulus under GA, and (3) repeat RETeval testing under GA. The 30 Hz cone flicker amplitudes and implicit times from the three methods were compared. Negative and positive predictive values were calculated by applying a previously established 5 μV amplitude cut-off. Results: Thirty patients ≤18 years of age were enrolled. Impaired conventional ERGs were found in 18 patients. Compared to conventional ERG under GA, RETeval cone flicker amplitudes were smaller before GA (mean difference, −42.2 ± 45.3 μV) and under GA (−37.1 ± 44.5 μV), likely due to skin electrode; and implicit times were shorter before GA (−1.06 ± 2.83 ms) and longer under GA (1.28 ± 4.12 ms), likely due to GA. Comparing RETeval responses before and under GA, the amplitudes were lower (−3.05 ± 6.82 μV), and implicit times were shorter (−2.25 ± 3.28 μV) before GA. Overall, the positive predictive value of the RETeval was 85%; the negative predictive value, 90%. Conclusions: The unsedated handheld RETeval 30 Hz cone flicker ERG is a feasible screening test for detecting cone dysfunction in pediatric patients. Full-protocol ERG is needed when screening ERG is reduced, equivocal, or clinically warranted. 2020-01-27T10:09:24Z 2020-01-27T10:09:24Z 2019-02-01 Article Journal of AAPOS. Vol.23, No.1 (2019), 34.e1-34.e5 10.1016/j.jaapos.2018.09.009 15283933 10918531 2-s2.0-85060875248 https://repository.li.mahidol.ac.th/handle/123456789/51918 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060875248&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine |
spellingShingle |
Medicine Carla J. Osigian Sara F. Grace Kara M. Cavuoto William J. Feuer Mehdi Tavakoli Piangporn Saksiriwutto Mu Liu Hilda Capo Byron L. Lam Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
description |
© 2019 American Association for Pediatric Ophthalmology and Strabismus Purpose: To assess the RETeval (LKC Technologies, Gaithersburg, MD) handheld electroretingram (ERG) device as a screening tool for cone dysfunction in pediatric patients by comparing it to conventional ERG. Methods: Patients scheduled for ERG under general anesthesia (GA) underwent three tests: (1) RETeval standard 30 Hz cone flicker ERG using skin electrodes prior to GA, (2) E3 Diagnosys (Diagnosys LLC, Lowell, MA) conventional complete standard protocol full-field ERG using bipolar contact lens electrodes and handheld stimulus under GA, and (3) repeat RETeval testing under GA. The 30 Hz cone flicker amplitudes and implicit times from the three methods were compared. Negative and positive predictive values were calculated by applying a previously established 5 μV amplitude cut-off. Results: Thirty patients ≤18 years of age were enrolled. Impaired conventional ERGs were found in 18 patients. Compared to conventional ERG under GA, RETeval cone flicker amplitudes were smaller before GA (mean difference, −42.2 ± 45.3 μV) and under GA (−37.1 ± 44.5 μV), likely due to skin electrode; and implicit times were shorter before GA (−1.06 ± 2.83 ms) and longer under GA (1.28 ± 4.12 ms), likely due to GA. Comparing RETeval responses before and under GA, the amplitudes were lower (−3.05 ± 6.82 μV), and implicit times were shorter (−2.25 ± 3.28 μV) before GA. Overall, the positive predictive value of the RETeval was 85%; the negative predictive value, 90%. Conclusions: The unsedated handheld RETeval 30 Hz cone flicker ERG is a feasible screening test for detecting cone dysfunction in pediatric patients. Full-protocol ERG is needed when screening ERG is reduced, equivocal, or clinically warranted. |
author2 |
The University of North Carolina at Chapel Hill |
author_facet |
The University of North Carolina at Chapel Hill Carla J. Osigian Sara F. Grace Kara M. Cavuoto William J. Feuer Mehdi Tavakoli Piangporn Saksiriwutto Mu Liu Hilda Capo Byron L. Lam |
format |
Article |
author |
Carla J. Osigian Sara F. Grace Kara M. Cavuoto William J. Feuer Mehdi Tavakoli Piangporn Saksiriwutto Mu Liu Hilda Capo Byron L. Lam |
author_sort |
Carla J. Osigian |
title |
Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
title_short |
Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
title_full |
Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
title_fullStr |
Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
title_full_unstemmed |
Assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
title_sort |
assessing nonsedated handheld cone flicker electroretingram as a screening test in pediatric patients: comparison to sedated conventional cone flicker electroretinogram |
publishDate |
2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/51918 |
_version_ |
1763492211507331072 |