A randomized controlled trial of three-versus five-day artemether-lumefantrine regimens for treatment of uncomplicated Plasmodium falciparum Malaria in Pregnancy in Africa

• Main Authors: Marie A. Onyamboko, Richard M. Hoglund, Sue J. Lee, Charlie Kabedi, Daddy Kayembe, Benjamin B. Badjanga, Gareth D.H. Turner, Nikky V. Jackson, Joel Tarning, Rose McGready, Francois Nosten, Nicholas J. White, Nicholas P.J. Day, Caterina Fanello
• Other Authors: Universite de Kinshasa
• Format: Article
• Published: 2020
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/53874
• Institution: Mahidol University

Copyright © 2020 Onyamboko et al. Artemether-lumefantrine antimalarial efficacy in pregnancy could be compromised by reduced drug exposure. Population-based simulations suggested that therapeutic efficacy would be improved if the treatment duration was increased. We assessed the efficacy, tolerabili...