Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial

• Main Authors: Thomas J. Peto, Rupam Tripura, James J. Callery, Dysoley Lek, Ho Dang Trung Nghia, Chea Nguon, Nguyen Thi Huyen Thuong, Rob W. van der Pluijm, Nguyen Thi Phuong Dung, Meas Sokha, Vo Van Luong, Le Thanh Long, Yok Sovann, Jureeporn Duanguppama, Naomi Waithira, Richard M. Hoglund, Palang Chotsiri, Nguyen Hoang Chau, Andrea Ruecker, Chanaki Amaratunga, Mehul Dhorda, Olivo Miotto, Richard J. Maude, Huy Rekol, Kesinee Chotivanich, Joel Tarning, Lorenz von Seidlein, Mallika Imwong, Mavuto Mukaka, Nicholas P.J. Day, Tran Tinh Hien, Nicholas J. White, Arjen M. Dondorp
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/74487
• Institution: Mahidol University

Background: Late treatment failures after artemisinin-based combination therapies (ACTs) for falciparum malaria have increased in the Greater Mekong subregion in southeast Asia. Addition of amodiaquine to artemether–lumefantrine could provide an efficacious treatment for multidrug-resistant infectio...