High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children
Copyright © 2020 American Society for Microbiology. All Rights Reserved. Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter (pfcrt) 76T allele. The tolerability of...
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th-mahidol.538772020-03-26T12:14:31Z High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children Johan Ursing Lars Rombo Staffan Eksborg Lena Larson Anita Bruvoll Joel Tarning Amabelia Rodrigues Poul Erik Kofoed Danderyd Hospital Mahidol University Karolinska Institutet Nuffield Department of Clinical Medicine Uppsala Universitet Kolding Sygehus Sörmland County Council Indepth Network Medicine Pharmacology, Toxicology and Pharmaceutics Copyright © 2020 American Society for Microbiology. All Rights Reserved. Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter (pfcrt) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with uncomplicated malaria were given 10 mg/kg of chloroquine twice daily for 2 days and 5 mg/kg twice daily on the third day. Fifteen additional children were given 5 mg/kg twice daily for 2 more days. Chloroquine concentrations, blood pressure, electrocardiograms (ECGs), parasite density, and adverse events were assessed until day 28. Both dosages were well tolerated, and symptoms resolved by day 3 in parallel with increasing chloroquine concentrations. The median corrected QT (QTc) interval was 12 to 26 ms higher at expected peak concentrations than at day 0 (P < 0.001). Pfcrt 76T was associated with delayed parasite clearance. Day 28 clinical and parasitological responses against P. falciparum with pfcrt 76T were 57% (4/7) and 67% (4/6) after treatment with 50 and 70 mg/kg, respectively. Dosages were well tolerated, and no severe cardiac adverse events occurred. The QTc interval increase was similar to that found in adults taking 25 mg/kg of chloroquine. 2020-03-26T05:08:51Z 2020-03-26T05:08:51Z 2020-01-01 Article Antimicrobial Agents and Chemotherapy. Vol.64, No.3 (2020) 10.1128/AAC.01846-19 10986596 00664804 2-s2.0-85079888788 https://repository.li.mahidol.ac.th/handle/123456789/53877 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079888788&origin=inward |
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Medicine Pharmacology, Toxicology and Pharmaceutics Johan Ursing Lars Rombo Staffan Eksborg Lena Larson Anita Bruvoll Joel Tarning Amabelia Rodrigues Poul Erik Kofoed High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children |
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Copyright © 2020 American Society for Microbiology. All Rights Reserved. Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter (pfcrt) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were assessed in this study. Fifteen 4- to 8-year-old children with uncomplicated malaria were given 10 mg/kg of chloroquine twice daily for 2 days and 5 mg/kg twice daily on the third day. Fifteen additional children were given 5 mg/kg twice daily for 2 more days. Chloroquine concentrations, blood pressure, electrocardiograms (ECGs), parasite density, and adverse events were assessed until day 28. Both dosages were well tolerated, and symptoms resolved by day 3 in parallel with increasing chloroquine concentrations. The median corrected QT (QTc) interval was 12 to 26 ms higher at expected peak concentrations than at day 0 (P < 0.001). Pfcrt 76T was associated with delayed parasite clearance. Day 28 clinical and parasitological responses against P. falciparum with pfcrt 76T were 57% (4/7) and 67% (4/6) after treatment with 50 and 70 mg/kg, respectively. Dosages were well tolerated, and no severe cardiac adverse events occurred. The QTc interval increase was similar to that found in adults taking 25 mg/kg of chloroquine. |
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Danderyd Hospital |
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Danderyd Hospital Johan Ursing Lars Rombo Staffan Eksborg Lena Larson Anita Bruvoll Joel Tarning Amabelia Rodrigues Poul Erik Kofoed |
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Article |
author |
Johan Ursing Lars Rombo Staffan Eksborg Lena Larson Anita Bruvoll Joel Tarning Amabelia Rodrigues Poul Erik Kofoed |
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Johan Ursing |
title |
High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children |
title_short |
High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children |
title_full |
High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children |
title_fullStr |
High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children |
title_full_unstemmed |
High-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar QT interval prolongation as standard-dose chloroquine in children |
title_sort |
high-dose chloroquine for uncomplicated plasmodium falciparum malaria is well tolerated and causes similar qt interval prolongation as standard-dose chloroquine in children |
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2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/53877 |
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1763488620948226048 |