Aqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activity
© 2020, © 2020 Taylor & Francis Group, LLC. Aqueous extracts of selected Thai medicinal plants were assessed for anti-HIV-1 activities in syncytium reduction assay using ∆tat/revMC99/1A2 system and reverse transcription (RT) inhibition assay. Results showed that all the plant extracts inhibite...
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/54654 |
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| Institution: | Mahidol University |
| Summary: | © 2020, © 2020 Taylor & Francis Group, LLC. Aqueous extracts of selected Thai medicinal plants were assessed for anti-HIV-1 activities in syncytium reduction assay using ∆tat/revMC99/1A2 system and reverse transcription (RT) inhibition assay. Results showed that all the plant extracts inhibited viral syncytium formation with the effective concentrations at 50% (EC50) ranging from 33.9 to 112 µg mL−1. The EC50 values indicated that the extracts were not toxic to 1A2 cells. The selectivity index (SI) ranged from 2.0 to > 6.6. The antiviral activity found in each plant was not due to the inhibition of viral reverse transcriptase enzyme. |
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