Aqueous Extracts of Thai Medicinal Plants Possess anti-HIV-1 Activity

• Main Authors: Sathit Panvilai, Chanita Napaswad, Jitra Limthongkul, Radeekorn Akkarawongsapat
• Other Authors: Bansomdejchaopraya Rajabhat University
• Format: Article
• Published: 2020
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/54654
• Institution: Mahidol University

© 2020, © 2020 Taylor & Francis Group, LLC. Aqueous extracts of selected Thai medicinal plants were assessed for anti-HIV-1 activities in syncytium reduction assay using ∆tat/revMC99/1A2 system and reverse transcription (RT) inhibition assay. Results showed that all the plant extracts inhibited viral syncytium formation with the effective concentrations at 50% (EC50) ranging from 33.9 to 112 µg mL−1. The EC50 values indicated that the extracts were not toxic to 1A2 cells. The selectivity index (SI) ranged from 2.0 to > 6.6. The antiviral activity found in each plant was not due to the inhibition of viral reverse transcriptase enzyme.