Pharmacogenetic assessment of tafenoquine efficacy in patients with Plasmodium vivax malaria

• Main Authors: Pamela L. St Jean, Gavin C.K.W. Koh, John J. Breton, Fe E.J. Espino, Tran T. Hien, Srivicha Krudsood, Marcus V.G. Lacerda, Alejandro Llanos-Cuentas, Chanthap Lon, Rezika Mohammed, Chayadol S. Namaik-Larp, Dhelio B. Pereira, David L. Saunders, Ivan D. Velez, Daniel Yilma, Maria F. Villegas, Stephan Duparc, Justin A. Green
• Other Authors: Oxford University Clinical Research Unit
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/57685
• Institution: Mahidol University

Plasmodium vivax has the largest geographic range of human malaria species and is challenging to manage and eradicate due to its ability to establish a dormant liver stage, the hypnozoite, which can reactivate leading to relapse. Until recently, the only treatment approved to kill hypnozoites was th...