Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes

© 2020 The Royal Society of Chemistry. MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort"antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR suppor...

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Main Authors:	Emily Lythell, Reynier Suardíaz, Philip Hinchliffe, Chonnikan Hanpaibool, Surawit Visitsatthawong, A. Sofia F. Oliveira, Eric J.M. Lang, Panida Surawatanawong, Vannajan Sanghiran Lee, Thanyada Rungrotmongkol, Natalie Fey, James Spencer, Adrian J. Mulholland
Other Authors:	University of Malaya
Format:	Article
Published:	2020
Subjects:	Chemical Engineering Chemistry Materials Science
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/57794
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Institution:	Mahidol University

id	th-mahidol.57794
record_format	dspace
spelling	th-mahidol.577942020-08-25T17:14:45Z Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes Emily Lythell Reynier Suardíaz Philip Hinchliffe Chonnikan Hanpaibool Surawit Visitsatthawong A. Sofia F. Oliveira A. Sofia F. Oliveira Eric J.M. Lang Panida Surawatanawong Vannajan Sanghiran Lee Thanyada Rungrotmongkol Natalie Fey James Spencer Adrian J. Mulholland University of Malaya Chulalongkorn University Universidad Complutense de Madrid University of Portsmouth University of Bristol Mahidol University Chemical Engineering Chemistry Materials Science © 2020 The Royal Society of Chemistry. MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort"antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono-rather than multinuclear member of the alkaline phosphatase superfamily. 2020-08-25T09:23:38Z 2020-08-25T09:23:38Z 2020-06-25 Article Chemical Communications. Vol.56, No.50 (2020), 6874-6877 10.1039/d0cc02520h 1364548X 13597345 2-s2.0-85087096464 https://repository.li.mahidol.ac.th/handle/123456789/57794 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087096464&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Chemical Engineering Chemistry Materials Science
spellingShingle	Chemical Engineering Chemistry Materials Science Emily Lythell Reynier Suardíaz Philip Hinchliffe Chonnikan Hanpaibool Surawit Visitsatthawong A. Sofia F. Oliveira A. Sofia F. Oliveira Eric J.M. Lang Panida Surawatanawong Vannajan Sanghiran Lee Thanyada Rungrotmongkol Natalie Fey James Spencer Adrian J. Mulholland Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
description	© 2020 The Royal Society of Chemistry. MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort"antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono-rather than multinuclear member of the alkaline phosphatase superfamily.
author2	University of Malaya
author_facet	University of Malaya Emily Lythell Reynier Suardíaz Philip Hinchliffe Chonnikan Hanpaibool Surawit Visitsatthawong A. Sofia F. Oliveira A. Sofia F. Oliveira Eric J.M. Lang Panida Surawatanawong Vannajan Sanghiran Lee Thanyada Rungrotmongkol Natalie Fey James Spencer Adrian J. Mulholland
format	Article
author	Emily Lythell Reynier Suardíaz Philip Hinchliffe Chonnikan Hanpaibool Surawit Visitsatthawong A. Sofia F. Oliveira A. Sofia F. Oliveira Eric J.M. Lang Panida Surawatanawong Vannajan Sanghiran Lee Thanyada Rungrotmongkol Natalie Fey James Spencer Adrian J. Mulholland
author_sort	Emily Lythell
title	Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
title_short	Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
title_full	Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
title_fullStr	Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
title_full_unstemmed	Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
title_sort	resistance to the "last resort" antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in mcr enzymes
publishDate	2020
url	https://repository.li.mahidol.ac.th/handle/123456789/57794
_version_	1763491308950781952

Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes

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