Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes

Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes

© 2020 The Royal Society of Chemistry. MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort"antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR suppor...

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Bibliographic Details
Main Authors: Emily Lythell, Reynier Suardíaz, Philip Hinchliffe, Chonnikan Hanpaibool, Surawit Visitsatthawong, A. Sofia F. Oliveira, Eric J.M. Lang, Panida Surawatanawong, Vannajan Sanghiran Lee, Thanyada Rungrotmongkol, Natalie Fey, James Spencer, Adrian J. Mulholland
Other Authors: University of Malaya
Format: Article
Published: 2020
Subjects:
Chemical Engineering
Chemistry
Materials Science
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/57794
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Institution: Mahidol University

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