Pathogen-associated molecules from gut translocation enhance severity of cecal ligation and puncture sepsis in iron-overload β-thalassemia mice

• Main Authors: Kritsanawan Sae-Khow, Awirut Charoensappakit, Peerapat Visitchanakun, Wilasinee Saisorn, Saovaros Svasti, Suthat Fucharoen, Asada Leelahavanichkul
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2020
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/59994
• Institution: Mahidol University

© 2020 Sae-khow et al. Introduction: Systemic inflammation induced by gut translocation of lipopolysaccharide (LPS), a major component of Gram-negative bacteria, in thalassemia with iron-overload worsens sepsis. However, the impact of (1→3)-β-D-glucan (BG), a major fungal molecule, in iron-overload...