The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
BACKGROUND: Lumefantrine and atovaquone are highly lipophilic anti-malarial drugs. As a consequence absorption is increased when the drugs are taken together with a fatty meal, but the free fraction of active drug decreases in the presence of triglyceride-rich plasma lipoproteins. In this study, the...
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Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
2012
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Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/709 |
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Institution: | Mahidol University |
Language: | English |