The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum

• Main Authors: Kesinee Chotivanich, เกศินี โชติวานิช, Mathirut Mungthin, มฑิรุทธ มุ่งถิ่น, Ronnatrai Ruengweerayuth, Rachanee Udomsangpetc, รัชนีย์ อุดมแสงเพ็ชร, Dondorp, Arjen M., Pratap Singhasivanon, ประตาป สิงหศิวานนท์, Sasithon Pukrittayakamee, ศศิธร ผู้กฤตยาคามี, White, Nicholas J.
• Format: Article
• Language: English
• Published: 2012
• Subjects: Anti-malarial drugs; In vitro-susceptibility; Malaria; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/709
• Institution: Mahidol University

BACKGROUND: Lumefantrine and atovaquone are highly lipophilic anti-malarial drugs. As a consequence absorption is increased when the drugs are taken together with a fatty meal, but the free fraction of active drug decreases in the presence of triglyceride-rich plasma lipoproteins. In this study, the...