Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults.

• Main Authors: Sumonmal Uttayamakul, สุมนมาลย์ อุทยมกุล, Sirirat Likanonsakul, ศิริรัตน์ ลิกานนท์สกุล, Weerawat Manosuthi, วีรวัฒน์ มโนสุทธิ, Nuanjun Wichukchinda, Thareerat Kalambaheti, ธารีรัตน์ กะลัมพะเหติ, Nakayama, Emi E., Shioda, Tatsuo, Srisin Khusmith, ศรีสิน คูสมิทธิ์
• Format: Article
• Language: English
• Published: 2013
• Subjects: HIV; Efavirenz; Nevirapine; Plasma; Rifampin; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/726
• Institution: Mahidol University

BACKGROUND: Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical component of tuberculosis (TB) therapy is a potent inducer of CYP enzyme activity. Polymorphisms of CYP2B6 and CYP3A4 are associated with...