Differential Effects of a Novel Opioid Ligand UTA1003 on Antinociceptive Tolerance and Motor Behaviour

• Main Authors: Alok K. Paul, Krystel L. Woolley, Mohammed Rahmatullah, Polrat Wilairatana, Jason A. Smith, Nuri Gueven, Nikolas Dietis
• 其他作者: University of Cyprus Medical School
• 格式: Article
• 出版: 2022
• 主題: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/73253
• 機構: Mahidol University

Analgesic tolerance is a major problem in the clinic for the maintenance of opioid-induced long-term pain relief. Opioids with mixed activity on multiple opioid receptors promise reduced antinociceptive tolerance in preclinical studies, but these compounds typically show poor bioavail-ability upon o...