The Acquired Vulnerability Caused by CDK4/6 Inhibition Promotes Drug Synergism Between Oxaliplatin and Palbociclib in Cholangiocarcinoma

• Main Authors: Orawan Suppramote, Sunisa Prasopporn, Satinee Aroonpruksakul, Ben Ponvilawan, Jiradej Makjaroen, Monthira Suntiparpluacha, Krittiya Korphaisarn, Komgrid Charngkaew, Rawisak Chanwat, Trairak Pisitkun, Seiji Okada, Somponnat Sampattavanich, Siwanon Jirawatnotai
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73315
• Institution: Mahidol University

Cholangiocarcinoma (CCA) is one of the most difficult to treat cancers, and its nature of being largely refractory to most, if not all, current treatments results in generally poor prognosis and high mortality. Efficacious alternative therapies that can be used ubiquitously are urgently needed. Usin...