The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats

• Main Authors: Laongdao Thongnak, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Varanuj Chatsudthipong, Anusorn Lungkaphin
• Other Authors: Faculty of Medicine, Chiang Mai University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Environmental Science; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73385
• Institution: Mahidol University

Long-term use of a high-fat diet with high-fructose (HFF) intake could promote insulin resistance and induce lipid accumulation leading to kidney injury possibly via impairment of the autophagy process and enhancement of the inflammasome pathway. We investigated whether dapagliflozin as a monotherap...