B1 repetitive sequence methylation enhances wound healing of second-degree burns in rats

• Main Authors: Jiraroch Meevassana, Panupong Nacharoenkul, Jade Wititsuwannakul, Nakarin Kitkumthorn, Kevin J. Hamill, Apichai Angspatt, Apiwat Mutirangura
• Other Authors: Mahidol University, Faculty of Dentistry
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73407
• Institution: Mahidol University

The accumulation of DNA damage in burn wounds delays wound healing. DNA methylation by short interspersed nuclear element (SINE) small interfering (si) RNA prevents DNA damage and promotes cell proliferation. Therefore, SINE siRNA may be able to promote burn wound healing. Here, a SINE B1 siRNA was...