E8002 Reduces Adhesion Formation and Improves Joint Mobility in a Rat Model of Knee Arthrofibrosis

• Main Authors: Seiya Takada, Kentaro Setoyama, Kosuke Norimatsu, Shotaro Otsuka, Kazuki Nakanishi, Akira Tani, Tomomi Nakakogawa, Ryoma Matsuzaki, Teruki Matsuoka, Harutoshi Sakakima, Salunya Tancharoen, Ikuro Maruyama, Eiichiro Tanaka, Kiyoshi Kikuchi, Hisaaki Uchikado
• Other Authors: Kagoshima University Graduate School of Medical and Dental Sciences
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Chemistry; Computer Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73450
• Institution: Mahidol University

Knee arthrofibrosis is a common complication of knee surgery, caused by excessive scar tissue, which results in functional disability. However, no curative treatment has been established. E8002 is an anti-adhesion material that contains L-ascorbic acid, an antioxidant. We aimed to evaluate the effic...