Efficacy of Single-Dose Primaquine with Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis

• Main Authors: Kasia Stepniewska, Georgina S. Humphreys, Bronner P. Gonçalves, Elaine Craig, Roly Gosling, Philippe J. Guerin, Ric N. Price, Karen I. Barnes, Jaishree Raman, Menno R. Smit, Umberto D'Alessandro, Will J.R. Stone, Anders Bjorkman, Aaron M. Samuels, Maria I. Arroyo-Arroyo, Guido J.H. Bastiaens, Joelle M. Brown, Alassane Dicko, Badria B. El-Sayed, Salah Eldin G. Elzaki, Alice C. Eziefula, Simon Kariuki, Titus K. Kwambai, Amanda E. Maestre, Andreas Martensson, Dominic Mosha, Richard O. Mwaiswelo, Billy E. Ngasala, Joseph Okebe, Michelle E. Roh, Patrick Sawa, Alfred B. Tiono, Ingrid Chen, Chris J. Drakeley, Teun Bousema
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/74643
• Institution: Mahidol University

Background: Since the World Health Organization recommended single low-dose (0.25 mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant Plasmodium falciparum, several single-site studies have been conducted to...