Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria

• Main Authors: Benedikt Ley, Mohammad Shafiul Alam, Ari Winasti Satyagraha, Ching Swe Phru, Kamala Thriemer, Dagimawie Tadesse, Tamiru Shibiru, Asrat Hailu, Mohammad Golam Kibria, Mohammad Sharif Hossain, Hisni Rahmat, Jeanne R. Poespoprodjo, Wasif Ali Khan, Julie A. Simpson, Ric N. Price
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75003
• Institution: Mahidol University

Primaquine and tafenoquine are the only licensed drugs with activity against Plasmodium vivax hypnozoites but cause haemolysis in patients with glucose–6–phosphate dehydrogenase (G6PD) deficiency. Malaria also causes haemolysis, leading to the replacement of older erythrocytes with low G6PD activity...