Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion

• Main Authors: Miao, Miao, Wang, Zenglei, Yang, Zhaoqing, Yuan, Lili, Parker, Daniel M., Chaturong Putaporntip, Somchai Jongwutiwes, Xangsayarath, Phonepadith, Pongvongsa, Tiengkham, Moji, Hazuhiko, Tuong, Trinh Dinh, Abe, Tomoko, Nakazawa, Shusuke, Kyaw, Myat Phone, Yan, Guiyun, Jeeraphat Sirichaisinthop, Jetsumon Sattabongkot, เจตสุมน สัตตบงกช, Mu, Jianbing, Su, Xin-zhuan, Kaneko, Osamu, Cui, Liwang
• Format: Article
• Language: English
• Published: 2014
• Subjects: Genetic; Plasmodium falciparum; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/752
• Institution: Mahidol University

The recent detection of clinical Artemisinin (ART) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern. The mechanism of ART resistance is not clear; but the P. falciparum sarco/endoplasmic reticulum Ca(2+)-ATPase (PfSERCA or PfATP6)...