Synthesis and characterization of andrographolide derivatives as regulators of βapp processing in human cells

• Main Authors: Arpita Dey, Ran Chen, Feng Li, Subhamita Maitra, Jean Francois Hernandez, Guo Chun Zhou, Bruno Vincent
• Other Authors: Université de Montpellier
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75897
• Institution: Mahidol University

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, one of the main characteristics of which is the abnormal accumulation of amyloid peptide (Aβ) in the brain. Whereas β-secretase supports Aβ formation along the amyloidogenic processing of the β-amyloid precursor protein (βAPP), α-...