Interference on cytosolic DNA activation attenuates sepsis severity: Experiments on cyclic GMP–AMP synthase (cGAS) deficient mice

Interference on cytosolic DNA activation attenuates sepsis severity: Experiments on cyclic GMP–AMP synthase (cGAS) deficient mice

Although the enhanced responses against serum cell-free DNA (cfDNA) in cases of sepsis—a life-threatening organ dysfunction due to systemic infection—are understood, the influence of the cytosolic DNA receptor cGAS (cyclic guanosine monophosphate–adenosine monophosphate (GMP– AMP) synthase) on sepsi...

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Bibliographic Details
Main Authors: Peerapat Visitchanakun, Warerat Kaewduangduen, Awirut Chareonsappakit, Paweena Susantitaphong, Prapaporn Pisitkun, Patcharee Ritprajak, Natavudh Townamchai, Asada Leelahavanichkul
Other Authors: Ramathibodi Hospital
Format: Article
Published: 2022
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Chemistry
Computer Science
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/75983
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/75983

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