High-throughput quantitation method for amodiaquine and desethylamodiaquine in plasma using supported liquid extraction technology

• Main Authors: Karnrawee Kaewkhao, Joel Tarning, Daniel Blessborn
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76085
• Institution: Mahidol University

Amodiaquine is a drug used for treatment of malaria and is often used in combination with artesunate in areas where malaria parasites are still susceptible to amodiaquine. Liquid chromatography tandem-mass spectrometry was used to quantify amodiaquine and its active metabolite, desethylamodiaquine,...