Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial

• Main Authors: John Frater, Katie J. Ewer, Ane Ogbe, Mathew Pace, Sandra Adele, Emily Adland, Jasmini Alagaratnam, Parvinder K. Aley, Mohammad Ali, M. Azim Ansari, Anna Bara, Mustapha Bittaye, Samantha Broadhead, Anthony Brown, Helen Brown, Federica Cappuccini, Enya Cooney, Wanwisa Dejnirattisai, Christina Dold, Cassandra Fairhead, Henry Fok, Pedro M. Folegatti, Jamie Fowler, Charlotte Gibbs, Anna L. Goodman, Daniel Jenkin, Mathew Jones, Rebecca Makinson, Natalie G. Marchevsky, Yama F. Mujadidi, Hanna Nguyen, Lucia Parolini, Claire Petersen, Emma Plested, Katrina M. Pollock, Maheshi N. Ramasamy, Sarah Rhead, Hannah Robinson, Nicola Robinson, Patpong Rongkard, Fiona Ryan, Sonia Serrano, Timothy Tipoe, Merryn Voysey, Anele Waters, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Gavin R. Screaton, Alan Winston, Adrian V.S. Hill, Sarah C. Gilbert, Andrew J. Pollard, Sarah Fidler, Julie Fox, Teresa Lambe, Marion E.E. Watson, Rinn Song, Paola Cicconi, Angela M. Minassian, Sagida Bibi, Simon Kerridge, Nisha Singh, Catherine M. Green, Alexander D. Douglas, Alison M. Lawrie, Elizabeth A. Clutterbuck
• Other Authors: NIHR Imperial Biomedical Research Centre
• Format: Article
• Published: 2022
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77248
• Institution: Mahidol University

Background: Data on vaccine immunogenicity against SARS-CoV-2 are needed for the 40 million people globally living with HIV who might have less functional immunity and more associated comorbidities than the general population. We aimed to explore safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD...