Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β<sup>0</sup>-thalassemia/hemoglobin E erythroid cells

Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β<sup>0</sup>-thalassemia/hemoglobin E erythroid cells

Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-tha-lassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultu...

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Main Authors: Woratree Kaewsakulthong, Phitchapa Pongpaksupasin, Tiwaporn Nualkaew, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn, Orapan Sripichai
Other Authors: Siriraj Hospital
Format: Article
Published: 2022
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/77671
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/77671

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