Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β<sup>0</sup>-thalassemia/hemoglobin E erythroid cells

Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β<sup>0</sup>-thalassemia/hemoglobin E erythroid cells

Induction of fetal hemoglobin (HbF) ameliorates the clinical severity of β-tha-lassemias. Histone methyltransferase LSD1 enzyme removes methyl groups from the activating chromatin mark histone 3 lysine 4 at silenced genes, including the γ-globin genes. LSD1 inhibitor RN-1 induces HbF levels in cultu...

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Bibliographic Details
Main Authors:	Woratree Kaewsakulthong, Phitchapa Pongpaksupasin, Tiwaporn Nualkaew, Suradej Hongeng, Suthat Fucharoen, Natee Jearawiriyapaisarn, Orapan Sripichai
Other Authors:	Siriraj Hospital
Format:	Article
Published:	2022
Subjects:	Medicine
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/77671
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Institution:	Mahidol University

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