Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial

• Main Authors: Mainga Hamaluba, Rob W. van der Pluijm, Joseph Weya, Patricia Njuguna, Mwanajuma Ngama, Peter Kalume, Gabriel Mwambingu, Caroline Ngetsa, Juliana Wambua, Mwanamvua Boga, Neema Mturi, Altaf A. Lal, Arshad Khuroo, Walter R.J. Taylor, Sónia Gonçalves, Olivo Miotto, Mehul Dhorda, Brian Mutinda, Mavuto Mukaka, Naomi Waithira, Richard M. Hoglund, Mallika Imwong, Joel Tarning, Nicholas P.J. Day, Nicholas J. White, Philip Bejon, Arjen M. Dondorp
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77832
• Institution: Mahidol University

Background: Triple antimalarial combination therapies combine potent and rapidly cleared artemisinins or related synthetic ozonides, such as arterolane, with two, more slowly eliminated partner drugs to reduce the risk of resistance. We aimed to assess the safety, tolerability, and efficacy of arter...