Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated with Piperaquine Resistance in Northern Cambodia

• Main Authors: Biraj Shrestha, Zalak Shah, Andrew P. Morgan, Piyaporn Saingam, Chaiyaporn Chaisatit, Suwanna Chaorattanakawee, Chantida Praditpol, Nonlawat Boonyalai, Paphavee Lertsethtakarn, Mariusz Wojnarski, Molly Deutsch-Feldman, Matthew Adams, Darapiseth Sea, Soklyda Chann, Stuart D. Tyner, Charlotte A. Lanteri, Michele D. Spring, David L. Saunders, Philip L. Smith, Chanthap Lon, Panita Gosi, Somethy Sok, Prom Satharath, Huy Rekol, Dysoley Lek, Brian A. Vesely, Jessica T. Lin, Norman C. Waters, Shannon Takala-Harrison
• Other Authors: The University of North Carolina at Chapel Hill
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77853
• Institution: Mahidol University

Background: Newly emerged mutations within the Plasmodium falciparum chloroquine resistance transporter (PfCRT) can confer piperaquine resistance in the absence of amplified plasmepsin II (pfpm2). In this study, we estimated the prevalence of co-circulating piperaquine resistance mutations in P. fal...