A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.

• Main Authors: Ohashi, Jun, Naka, Izumi, Doi, Akihiro, Jintana Patarapotikul, จินตนา ภัทรโพธิกุล, Hathairad Hananantachai, Noppadon Tangpukdee, นพดล ตั้งภักดี, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Tokunaga, Katsushi
• Other Authors: Mahidol University. Faculty of Tropical Medicine
• Format: Article
• Language: English
• Published: 2013
• Subjects: Alleles; Genetic predisposition to disease; Interleukin 1 receptor antagonist protein; Interleukin-1; Interleukin-1beta; Malaria, Cerebral; Mutation; Polymorphism, genetic; Promoter regions, genetic; Sialoglycoproteins; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/807
• Institution: Mahidol University

IL-1beta and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T. METHODS: To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malaria and 203 mild malaria patients). RESULTS: In this population, IL1B -31C>T and IL1RA VNTR were detected, while IL1B 3953C>T (i.e., IL1B 3953T) was not observed in the polymorphism screening for 32 patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients showed no significant association of these polymorphisms with cerebral malaria. CONCLUSION: The present results suggest that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria.