A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.
IL-1beta and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T. METHODS: To examine whether polymorphisms in IL1B and IL...
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th-mahidol.8072023-03-30T20:16:06Z A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. Ohashi, Jun Naka, Izumi Doi, Akihiro Jintana Patarapotikul จินตนา ภัทรโพธิกุล Hathairad Hananantachai Noppadon Tangpukdee นพดล ตั้งภักดี Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ Tokunaga, Katsushi Mahidol University. Faculty of Tropical Medicine Alleles Genetic predisposition to disease Interleukin 1 receptor antagonist protein Interleukin-1 Interleukin-1beta Malaria, Cerebral Mutation Polymorphism, genetic Promoter regions, genetic Sialoglycoproteins Open Access article IL-1beta and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T. METHODS: To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malaria and 203 mild malaria patients). RESULTS: In this population, IL1B -31C>T and IL1RA VNTR were detected, while IL1B 3953C>T (i.e., IL1B 3953T) was not observed in the polymorphism screening for 32 patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients showed no significant association of these polymorphisms with cerebral malaria. CONCLUSION: The present results suggest that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria. 2013-01-02T06:33:20Z 2016-10-10T09:06:41Z 2013-01-02T06:33:20Z 2016-10-10T09:06:41Z 2005 2005-01-02 2005-08-14 Research Article Ohashi J, Naka I, Doi A, Patarapotikul J, Hananantachai H, Tangpukdee N, et al. A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. Malar J. 2005 Aug 14;4:38. 10.1186/1475-2875-4-38 1475-2875 (electronic) https://repository.li.mahidol.ac.th/handle/123456789/807 eng Mahidol University BioMed Central application/pdf |
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Alleles Genetic predisposition to disease Interleukin 1 receptor antagonist protein Interleukin-1 Interleukin-1beta Malaria, Cerebral Mutation Polymorphism, genetic Promoter regions, genetic Sialoglycoproteins Open Access article |
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Alleles Genetic predisposition to disease Interleukin 1 receptor antagonist protein Interleukin-1 Interleukin-1beta Malaria, Cerebral Mutation Polymorphism, genetic Promoter regions, genetic Sialoglycoproteins Open Access article Ohashi, Jun Naka, Izumi Doi, Akihiro Jintana Patarapotikul จินตนา ภัทรโพธิกุล Hathairad Hananantachai Noppadon Tangpukdee นพดล ตั้งภักดี Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ Tokunaga, Katsushi A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. |
description |
IL-1beta and IL-1RA levels are higher in the serum of cerebral
malaria patients than in patients with mild malaria. Recently, the level of IL1B
expression was reported to be influenced by a polymorphism in the promoter of
IL1, IL1B -31C>T.
METHODS: To examine whether polymorphisms in IL1B and IL1RA influence the
susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable
number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria
(109 cerebral malaria and 203 mild malaria patients).
RESULTS: In this population, IL1B -31C>T and IL1RA VNTR were detected, while IL1B
3953C>T (i.e., IL1B 3953T) was not observed in the polymorphism screening for 32
patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria
and 206 mild malaria patients showed no significant association of these
polymorphisms with cerebral malaria.
CONCLUSION: The present results suggest that IL1B -31C>T and IL1RA VNTR
polymorphisms do not play a crucial role in susceptibility or resistance to
cerebral malaria. |
author2 |
Mahidol University. Faculty of Tropical Medicine |
author_facet |
Mahidol University. Faculty of Tropical Medicine Ohashi, Jun Naka, Izumi Doi, Akihiro Jintana Patarapotikul จินตนา ภัทรโพธิกุล Hathairad Hananantachai Noppadon Tangpukdee นพดล ตั้งภักดี Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ Tokunaga, Katsushi |
format |
Article |
author |
Ohashi, Jun Naka, Izumi Doi, Akihiro Jintana Patarapotikul จินตนา ภัทรโพธิกุล Hathairad Hananantachai Noppadon Tangpukdee นพดล ตั้งภักดี Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ Tokunaga, Katsushi |
author_sort |
Ohashi, Jun |
title |
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. |
title_short |
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. |
title_full |
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. |
title_fullStr |
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. |
title_full_unstemmed |
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand. |
title_sort |
functional polymorphism in the il1b gene promoter, il1b -31c>t, is not associated with cerebral malaria in thailand. |
publishDate |
2013 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/807 |
_version_ |
1763490817610088448 |