IOX1 Fails to Reduce α-Globin and Mediates γ-Globin Silencing in Adult β<sup>0</sup>-Thalassemia/Hemoglobin E Erythroid Progenitor Cells
The accumulation of unbound α-globin chains in red blood cells is a crucial pathophysiology of β-thalassemia. IOX1 (5-carboxy-8-hydroxyquinoline) is a broad-spectrum 2-oxoglutarate (2OG)-dependent oxygenase inhibitor that can reduce α-globin mRNA expression in human cord blood erythroid progenitor c...
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| 格式: | Article |
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2023
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| 在線閱讀: | https://repository.li.mahidol.ac.th/handle/123456789/83651 |
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| 機構: | Mahidol University |