IOX1 Fails to Reduce α-Globin and Mediates γ-Globin Silencing in Adult β<sup>0</sup>-Thalassemia/Hemoglobin E Erythroid Progenitor Cells

IOX1 Fails to Reduce α-Globin and Mediates γ-Globin Silencing in Adult β<sup>0</sup>-Thalassemia/Hemoglobin E Erythroid Progenitor Cells

The accumulation of unbound α-globin chains in red blood cells is a crucial pathophysiology of β-thalassemia. IOX1 (5-carboxy-8-hydroxyquinoline) is a broad-spectrum 2-oxoglutarate (2OG)-dependent oxygenase inhibitor that can reduce α-globin mRNA expression in human cord blood erythroid progenitor c...

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Bibliographic Details
Main Author:	Khamphikham P.
Other Authors:	Mahidol University
Format:	Article
Published:	2023
Subjects:	Biochemistry, Genetics and Molecular Biology
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/83651
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Mahidol University

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