Pharmacokinetic considerations in seasonal malaria chemoprevention

African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months...

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Main Author: Chotsiri P.
Other Authors: Mahidol University
Format: Review
Published: 2023
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/84946
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spelling th-mahidol.849462023-06-19T00:22:54Z Pharmacokinetic considerations in seasonal malaria chemoprevention Chotsiri P. Mahidol University Immunology and Microbiology African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months and 5 years living in the Sahel region, a region of intense but seasonal malaria transmission. This intervention is now being considered for other regions of Africa where malaria parasites are more drug resistant. Dihydroartemisinin-piperaquine (DP), an artemisinin-based combination therapy (ACT), has proved to be highly effective and well tolerated in intermittent preventive treatment in pregnant women and children. This combination may be a suitable alternative for SMC. Understanding the safety, pharmacokinetic and pharmacodynamic properties of antimalarial combination therapies is crucial in optimising dosing. 2023-06-18T17:22:54Z 2023-06-18T17:22:54Z 2022-08-01 Review Trends in Parasitology Vol.38 No.8 (2022) , 673-682 10.1016/j.pt.2022.05.003 14715007 14714922 35688778 2-s2.0-85131809192 https://repository.li.mahidol.ac.th/handle/123456789/84946 SCOPUS
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Immunology and Microbiology
spellingShingle Immunology and Microbiology
Chotsiri P.
Pharmacokinetic considerations in seasonal malaria chemoprevention
description African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months and 5 years living in the Sahel region, a region of intense but seasonal malaria transmission. This intervention is now being considered for other regions of Africa where malaria parasites are more drug resistant. Dihydroartemisinin-piperaquine (DP), an artemisinin-based combination therapy (ACT), has proved to be highly effective and well tolerated in intermittent preventive treatment in pregnant women and children. This combination may be a suitable alternative for SMC. Understanding the safety, pharmacokinetic and pharmacodynamic properties of antimalarial combination therapies is crucial in optimising dosing.
author2 Mahidol University
author_facet Mahidol University
Chotsiri P.
format Review
author Chotsiri P.
author_sort Chotsiri P.
title Pharmacokinetic considerations in seasonal malaria chemoprevention
title_short Pharmacokinetic considerations in seasonal malaria chemoprevention
title_full Pharmacokinetic considerations in seasonal malaria chemoprevention
title_fullStr Pharmacokinetic considerations in seasonal malaria chemoprevention
title_full_unstemmed Pharmacokinetic considerations in seasonal malaria chemoprevention
title_sort pharmacokinetic considerations in seasonal malaria chemoprevention
publishDate 2023
url https://repository.li.mahidol.ac.th/handle/123456789/84946
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