Undescribed 2-quinolines, onanaenine A and B, from Cameroonian Vepris onanae (Rutaceae)
Leaves of herbarium specimen material of Vepris onanae, collected in Cameroon, have yielded two undescribed 2-quinolines, onanaenine A (1) and onanaenine B (2), alongside the known 6,7-dimethoxy-N-methylflindersine (3), evoxanthine (4), 6-methoxy-tecleanthine (5) and polybotrin. Compounds 1 and 2 we...
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| Format: | Article |
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2023
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| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/88302 |
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| Institution: | Mahidol University |
| Summary: | Leaves of herbarium specimen material of Vepris onanae, collected in Cameroon, have yielded two undescribed 2-quinolines, onanaenine A (1) and onanaenine B (2), alongside the known 6,7-dimethoxy-N-methylflindersine (3), evoxanthine (4), 6-methoxy-tecleanthine (5) and polybotrin. Compounds 1 and 2 were not cytotoxic against FM55 melanoma cells at a concentration up to 200 µM, and they did not show signs of stimulating fibroblast skin cells at concentrations, up to 20 µM. Vepris onanae, the source of the two new 2-quinoline alkaloids, is at high risk of extinction, being near-endemic to the threatened Bali-Ngemba forest of NW Region Cameroon. Bali Ngemba has already seen the global extinction of Vepris bali, before it could be researched for new compounds. |
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